Risk factors and protective measures for desmoid tumours in familial adenomatous polyposis: retrospective cohort study.

ABSTRACT:

Background

Familial adenomatous polyposis is a cancer-predisposing syndrome caused by germline pathogenic variants of the adenomatous polyposis coli gene, leading to numerous colorectal polyps and a high risk of colorectal cancer. Desmoid tumours have become significant in the management of familial adenomatous polyposis after a colectomy, yet the exact incidence remains undetermined due to a lack of dedicated surveillance.

Methods

This retrospective study accessed data from the prospectively maintained Hereditary Digestive Tumours Registry from 2000 to 2023. Desmoid-free survival was analysed using Cox regression and Kaplan-Meier curves.

Results

A total of 202 patients with familial adenomatous polyposis who underwent colorectal surgery were enrolled. Of the patients

SUBMITTER: Rausa E 

PROVIDER: S-EPMC11683362 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature