Asymmetrical Evolution of Promoter Methylation of Mammalian Genes after Duplication.

ABSTRACT: Even though gene duplication is a key source of new genes and evolutionary innovation, it is unclear how duplicates survive the period immediately following gene duplication, in which both copies are functionally redundant. In the absence of epigenetic silencing, the abundance of the gene product would double after gene duplication, which would often have deleterious effects. However, recent duplicates exhibit low expression levels, which could be at least partially explained by high levels of promoter methylation. What evolutionary paths lead to duplicate hypermethylation, and does it affect both duplicates or only one? Here, we compare levels of promoter methylation in 10 human and 16 mouse tissues, between singletons and duplicates and among human-mouse orthologs of different kinds (one

SUBMITTER: de la Fuente M 

PROVIDER: S-EPMC11683416 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature