Evolutionary Novelty of Apolipoprotein D Facilitates Metabolic Plasticity in Lepidopteran Wings.

ABSTRACT: Understanding metabolic plasticity of animal evolution is a fundamental challenge in evolutionary biology. Owing to the diversification of insect wing morphology and dynamic energy requirements, the molecular adaptation mechanisms underlying the metabolic pathways in wing evolution remain largely unknown. This study reveals the pivotal role of the duplicated Apolipoprotein D (ApoD) gene in lipid and energy homeostasis in the lepidopteran wing. ApoD underwent significant expansion in insects, with gene duplication and consistent retention observed in Lepidoptera. Notably, duplicated ApoD2 was highly expressed in lepidopteran wings and encoded a unique C-terminal tail, conferring distinct ligand-binding properties. Using Bombyx mori as a model organism, we integrated evolutionary analysis, m

SUBMITTER: Jia S 

PROVIDER: S-EPMC11683417 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature