Alterations in gut-derived uremic toxins before the onset of azotemic chronic kidney disease in cats.

ABSTRACT:

Background

Although gut-derived uremic toxins are increased in azotemic chronic kidney disease (CKD) in cats and implicated in disease progression, it remains unclear if augmented formation or retention of these toxins is associated with the development of renal azotemia.

Objectives

Assess the association between gut-derived toxins (ie, indoxyl-sulfate, p-cresyl-sulfate, and trimethylamine-N-oxide [TMAO]) and the onset of azotemic CKD in cats.

Animals

Forty-eight client-owned cats.

Methods

Nested case-control study, comparing serum and urine gut-derived uremic toxin abundance at 6-month intervals between initially healthy cats that developed azotemic CKD (n = 22) and a control group (n = 26) that remained healthy, using a targeted metabolomic approach.

Resul

SUBMITTER: Van Mulders L 

PROVIDER: S-EPMC11683462 | biostudies-literature | 2025 Jan-Feb

REPOSITORIES: biostudies-literature