Developing Gingerol-Based Analogs against Pseudomonas aeruginosa Infections.

ABSTRACT: Pseudomonas aeruginosa (P. aeruginosa), a Gram-negative opportunistic pathogen, produces virulent factors and forms biofilms through a quorum sensing (QS) mechanism. Modulating QS networks is considered an effective strategy for treating P. aeruginosa infections. Particularly, the rhl system, one of the QS networks, can be a potential target in treating patients with chronic infections. We previously discovered that gingerol acts as a RhlR antagonist of P. aeruginosa. Based on the chemical structure of gingerol, we have designed and synthesized gingerol derivatives by introducing various functional groups in the middle and tail regions. A comprehensive structure-activity relationship study showed that compound 5a substituted with phenyl group in th

SUBMITTER: Lim T 

PROVIDER: S-EPMC11683490 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature