Exploring the causal relationship of gut microbiota in nonunion: a Mendelian randomization analysis mediated by immune cell.

ABSTRACT:

Background

Emerging research indicates that gut microbiota (GM) are pivotal in the regulation of immune-mediated bone diseases. Nonunion, a bone metabolic disorder, has an unclear causal relationship with GM and immune cells. This study aims to elucidate the causal relationship between GM and nonunion using Mendelian Randomization (MR) and to explore the mediating role of immune cells.

Methods

Using a two-step, two-sample Mendelian randomization approach, this study explores the causal link between GM and nonunion, as well as the mediating role of immune cells in this relationship. Data were sourced from multiple cohorts and consortiums, including the MiBioGen consortium. GM data were derived from a recently published dataset of 473 gut microbiota, and nonunion data were obt

SUBMITTER: Yu YF 

PROVIDER: S-EPMC11683590 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature