Chronic cannabis use associated with subcortical topological reorganization of structural connectivity in adults.

ABSTRACT:

Background

Cannabis is commonly used in the United States. However, chronic cannabis use has been linked to alterations in white matter (WM) integrity. Studies investigating WM in people who use cannabis (PWC) have produced varying results, which may be due to a variety of factors, including a focus on individual WM tracts. Here, we examined WM connectivity using a module-based approach to help clarify whether cannabis use is associated with differences in WM organization.

Methods

Connectomics is used to map complex networks of inter and intra-connected cortical and subcortical regions. A key concept of brain organization is the presence of groups of densely interconnected regions, referred to as modules. Here, we used WM structural connectivity estimates to compare connecto

SUBMITTER: Bell RP 

PROVIDER: S-EPMC11683732 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature