Changes in 6-min walk test is an independent predictor of death in chronic heart failure with reduced ejection fraction.

ABSTRACT:

Aims

Functional capacity provides important clinical information in patients with heart failure (HF) and reduced ejection fraction (HFrEF). The 6-min walk test (6MWT) is a simple and inexpensive tool for assessing functional capacity and risk. Although change in 6MWT is frequently used as a surrogate outcome in HF trials, the association with mortality is unclear. We aimed to assess the prognostic importance of changes in 6MWT.

Methods and results

Patients with chronic HFrEF referred to HF outpatient clinics in Norway completed a 6MWT at the first visit (baseline) and at a stable follow-up visit after treatment optimization (follow-up). Absolute and relative changes in 6MWT were analysed in association with mortality risk using Cox regression models and flexible cubic spline

SUBMITTER: Myhre PL 

PROVIDER: S-EPMC11683857 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature