Night shift work and prostate cancer: a large cohort study from UK Biobank and Mendelian randomisation study.

ABSTRACT:

Objective

The global concern regarding the health implications of night shift work has escalated. Nevertheless, variations exist in the observed association between night shift work and prostate cancer (PCa). This study aims to systematically explore the association between night shift work and the risk of PCa.

Design

Cohort study and Mendelian randomisation (MR) study were used.

Setting

Cohort study data was from the UK Biobank (UKB). MR study using data was from the Finngen study and UKB through the Integrative Epidemiology Unit (IEU) Open Genome-Wide Association Study Project.

Participants

Participants without prior PCa in paid employment or self-employment were include in the current work schedule cohort, participants without PCa who provided employment his

SUBMITTER: Yang G 

PROVIDER: S-EPMC11683915 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature