Lactylation-driven TNFR2 expression in regulatory T cells promotes the progression of malignant pleural effusion.

ABSTRACT:

Background

Although tumor necrosis factor receptor 2 (TNFR2) has been recognized as an attractive next-generation candidate target for cancer immunotherapy, the factors that regulate the gene expression and their mechanistic effects on tumor-infiltrating regulatory T cells (Treg cells) remain poorly understood.

Methods

Single-cell RNA sequencing analysis was employed to analyze the phenotypic and functional differences between TNFR2⁺ Treg cells and TNFR2^- Treg cells. Malignant pleural effusion (MPE) from humans and mouse was used to investigate the potential mechanisms by which lactate regulates TNFR2 expression.

Results

Treg cells with high TNFR2 expression exhibited elevated levels of immune checkpoint molecules. Additionally, the high expressi

SUBMITTER: Xue Q 

PROVIDER: S-EPMC11683941 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature