Association between immunosuppressive medications and COVID-19 hospitalisation and death: a retrospective cohort study.

ABSTRACT:

Importance

Immunocompromised status is a risk factor for severe SARS-CoV-2 infection. Little is known about how systemic corticosteroid dose and concurrent use of immunosuppressants are associated with COVID-19 outcomes.

Objective

To assess the association between corticosteroid dose/duration and concurrent immunosuppressant use on COVID-19 hospitalisation and death in the era of COVID-19 vaccinations.

Design

This is a retrospective cohort study using a deidentified insurance claims database from 1 July 2020 to 30 June 30, 2022, with the risk period starting on 1 July 2021. Impact of corticosteroid exposures and concurrent use of other immunosuppressants was assessed with attributable risk analysis and Cox regression that included COVID-19 vaccination status and time-

SUBMITTER: Sechrist SJ 

PROVIDER: S-EPMC11683992 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature