Exploring Extended Warheads toward Developing Cysteine-Targeted Covalent Kinase Inhibitors.

ABSTRACT: In designing covalent kinase inhibitors (CKIs), the inclusion of electrophiles as attacking warheads demands careful choreography, ensuring not only their presence on the scaffold moiety but also their precise interaction with nucleophiles in the binding sites. Given the limited number of known electrophiles, exploring adjacent chemical space to broaden the palette of available electrophiles capable of covalent inhibition is desirable. Here, we systematically analyze the characteristics of warheads and the corresponding adjacent fragments for use in CKI design. We first collect all the released cysteine-targeted CKIs from multiple databases and create one CKI data set containing 16,961 kinase-inhibitor data points from 12,381 unique CKIs covering 146 kinases with accessible cysteines in th

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC11684028 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature