Disentangling the genetic overlap between ischemic stroke and obesity.

ABSTRACT:

Objective

Obesity has been recognized as a risk factor for cerebrovascular diseases, with observational studies suggesting a heightened incidence of stroke. However, the genetic epidemiology field has yet to reach a consensus on the causal relationship and genetic overlap between ischemic stroke (IS) and obesity.

Methods

We utilized linkage disequilibrium score regression, high-definition likelihood, and local analysis of variant associations to assess the genetic correlation between body mass index (BMI) and IS. Bidirectional Mendelian randomization was employed to infer causality. We identified shared risk single nucleotide polymorphisms (SNPs) through cross-trait meta-analyses and estimated heritability using summary statistics. Summary-data-based Mendelian randomization

SUBMITTER: Yang R 

PROVIDER: S-EPMC11684051 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature