Exploring the role of the Rab network in epithelial-to-mesenchymal transition.

ABSTRACT:

Motivation

Rab GTPases (Rabs) are crucial for membrane trafficking within mammalian cells, and their dysfunction is implicated in many diseases. This gene family plays a role in several crucial cellular processes. Network analyses can uncover the complete repertoire of interaction patterns across the Rab network, informing disease research, opening new opportunities for therapeutic interventions.

Results

We examined Rabs and their interactors in the context of epithelial-to-mesenchymal transition (EMT), an indicator of cancer metastasizing to distant organs. A Rab network was first established from analysis of literature and was gradually expanded. Our Python module, resnet, assessed its network resilience and selected an optimally sized, resilient Rab network for fur

SUBMITTER: Jaygude U 

PROVIDER: S-EPMC11684074 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature