Effect of freezing and thawing on ejaculated sperm and subsequent pregnancy and neonatal outcomes in IVF.

ABSTRACT:

Background

Techniques for sperm cryopreservation have exhibited their potential in male fertility preservation. The use of frozen-thawed sperm in in vitro fertilization (IVF) cycles is widespread today. However, many studies reported that cryopreservation might have adverse effects on sperm DNA integrity, motility, and fertilization, probably due to cold shock, intra- and extracellular ice crystals, and excess reactive oxygen species (ROS). Studies suggested that freezing and thawing impaired sperm viability and might adversely affect subsequent fertilization and pregnancy outcomes. The potential damage to fertilization and subsequent embryonic development and offspring health raises the concern on sperm cryopreservation. However, the above mentioned studies are limited to i

SUBMITTER: Xie Q 

PROVIDER: S-EPMC11684094 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature