Mettl3-Mediated m6A Modification is Essential for Visual Function and Retinal Photoreceptor Survival.

ABSTRACT:

Purpose

N6-methyladenosine (m6A) modification, one of the most common epigenetic modifications in eukaryotic mRNA, has been shown to play a role in the development and function of the mammalian nervous system by regulating the biological fate of mRNA. METTL3, the catalytically active component of the m6A methyltransferase complex, has been shown to be essential in development of in the retina. However, its role in the mature retina remains elusive. In this study we aim to investigate the in vivo function of Mettl3 in the photoreceptor cells using a conditional knockout allele of Mettl3.

Methods

Deletion of Mettl3 in rod cells led to progressive retinal degeneration, including progressive retinal thinning, impaired visual function, shortened photoreceptor outer segments (OS),

SUBMITTER: Jiang X 

PROVIDER: S-EPMC11684116 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature