Genome-wide analysis in northern Chinese twins identifies twelve new susceptibility loci for pulmonary function.

ABSTRACT:

Background

Previous genome-wide association studies (GWAS) have established association between genetic variants and pulmonary function across various ethnics, whereas such associations are scarcely reported in Chinese adults. Therefore, we conducted an GWAS to explore relationships between genetic variants and pulmonary function among middle-aged Chinese dizygotic twins and further validated the top variants using data from the UK Biobank (UKB).

Methods

In the discovery phase, 139 dizygotic twin pairs were drawn from the Qingdao Twin Registry. Pulmonary function was assessed using three parameters: forced expiratory volume the first second (FEV1), forced vital capacity (FVC), and FEV1/FVC ratio. GWAS was performed using GEMMA, Gene-based analysis was conducted by VEGAS2. An

SUBMITTER: Wang T 

PROVIDER: S-EPMC11684132 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature