Genetic insights into therapeutic targets for gout: evidence from a multi-omics mendelian randomization study.

ABSTRACT:

Background

Considering that the treatment of gout is poor, we performed a Mendelian randomization (MR) study to identify candidate biomarkers and therapeutic targets for gout.

Methods

A drug-targeted MR study was performed for gout by integrating the gout genome-wide association studies (GWAS) summary data and cis expression quantitative trait loci of 2,633 druggable genes from multiple cohorts. Summary data-based Mendelian randomization (SMR) analyses based on transcript and protein levels were further implemented to validate the reliability of the identified potential therapeutic targets for gout. Phenome-wide MR (Phe-MR) analysis was conducted in 1403 diseases to investigate incidental side effects of potential therapeutic targets for gout.

Results

Eight potential

SUBMITTER: Fan M 

PROVIDER: S-EPMC11684267 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature