Systematic review/meta-analysis on the role of CB1R regulation in sleep-wake cycle in rats.

ABSTRACT:

Objective

A systematic review/meta-analysis was conducted to investigate the effect of cannabinoid type-1 receptor (CB1R) regulation on the sleep-wake cycle of rats and to provide new ideas and evidence-based basis for clinical research on the treatment of sleep disorders.

Methods

We searched Cochrane Library, PubMed, Web of Science, Embase, Chinese Biomedicine Literature Database (CBM), China National Knowledge Infrastructure, WanFang, and VIP databases for relevant papers, about the effects of CB1R agonists/antagonists on sleep-wake cycle in rats, from inception to November 2023. Two reviewers performed study screening, data extraction, and risk of bias assessment using the SYRCLE's risk of bias tool. Meta-analysis was performed using RevMan 5.3 software. Heterogeneity tes

SUBMITTER: Xue J 

PROVIDER: S-EPMC11684501 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature