Transcriptome immune-regulatory differences between leprosy patients and type 1 reaction patients, before onset of symptoms.

ABSTRACT: Leprosy is a chronic disease of the skin and peripheral nerves caused by Mycobacterium leprae. A major public health and clinical problem are leprosy reactions, which are inflammatory episodes that often contribute to nerve damage and disability. Type I reversal reactions (T1R) can occur after microbiological cure of leprosy and affect up to 50% of leprosy patients. Early intervention to prevent T1R and, hence, nerve damage, is a major focus of current leprosy control efforts. In a prospective study, we enrolled and collected samples from 32 leprosy patients before the onset of T1R. Whole blood aliquots were challenged with M. leprae sonicate or media and total RNA was extracted. After a three-year follow-up, the transcriptomic response was compared between cells from 22 patients who remai

SUBMITTER: Correa-Macedo W 

PROVIDER: S-EPMC11684701 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature