Network pharmacology and molecular docking to explore mechanisms of clozapine-induced cardiac arrest.

ABSTRACT:

Background

Clozapine is superior to all other antipsychotics in treating schizophrenia in terms of its curative efficacy; however, this drug is prescribed only as a last resort in the treatment of schizophrenia, given its potential to induce cardiac arrest. The mechanism of clozapine-induced cardiac arrest remains unclear, so we aimed to elucidate the potential mechanisms of clozapine-induced cardiac arrest using network pharmacology and molecular docking.

Methods

We identified and analyzed the overlap between potential cardiac arrest-related target genes and clozapine target genes. We conducted Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. We then constructed a protein-protein interaction (PPI) network and screened the core targe

SUBMITTER: Chen X 

PROVIDER: S-EPMC11684924 | biostudies-literature | 2025 Jan-Feb

REPOSITORIES: biostudies-literature