Racial Disparities and Achievement of the Low Lupus Disease Activity State: A CARRA Registry Study.

ABSTRACT:

Objective

Differential disease control may contribute to racial disparities in outcomes of childhood-onset systemic lupus erythematosus (cSLE). We evaluated associations of race and individual- or neighborhood-level social determinants of health (SDoH) with achievement of low lupus disease activity state (LLDAS), a clinically relevant treatment target.

Methods

In this cSLE cohort study using the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry, the primary exposure was self-reported race and ethnicity, and collected SDoH included insurance status and area deprivation index (ADI). Outcomes included LLDAS, disease activity, and time-averaged prednisone exposure. Associations among race and ethnicity, SDoH, and disease activity were estimated with multiva

SUBMITTER: Soulsby WD 

PROVIDER: S-EPMC11684980 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature