The relationship between respiratory symptoms and frailty: findings from observational and Mendelian randomization analyses.

ABSTRACT:

Introduction

As ageing accelerates, frailty increasingly impacts public health. Cough, sputum, wheezing and dyspnea are common respiratory symptoms, and the relationship to frailty is unclear. We aimed to analyze the relationship between respiratory symptoms and frailty.

Methods

Cross-sectional and Mendelian randomization (MR) studies were used. Cross-sectional data involved 14,021 participants from the National Health and Nutrition Examination Survey (NHANES). Logistic and linear regression were used to analyze the relationship between respiratory symptoms (cough, sputum, wheezing, dyspnea) and frailty. We adjusted for multiple variables and used propensity score matching (PSM). Mediation analysis was used to explore the role of inflammatory markers and age in the relations

SUBMITTER: Ruan Z 

PROVIDER: S-EPMC11685262 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature