Identification and analysis of immune cell-related genes in cutaneous squamous cell carcinoma and drug network prediction.

ABSTRACT: Cutaneous squamous cell carcinoma (CSCC) is a malignant skin tumor characterized by the abnormal proliferation of keratinocytes. Immune cells have a very important role in the development of CSCC. Hence, it was vital to screen the immune cell-related biomarkers for the treatment of CSCC. Gene set variation analysis (GSVA) and immune infiltration analysis were utilised to obtain key immune cells. Weighted gene co-expression network analysis (WGCNA) was conducted to screen key module genes related to immune cell. At the same time, differential analysis was performed to find the differentially expressed genes (DEGs) between CSCC and normal samples. The candidate genes related to immune cell in CSCC patients were certificated by Venn diagram. Protein-protein interaction (PPI) network and recei

SUBMITTER: Wang B 

PROVIDER: S-EPMC11685271 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature