Concurrent optoacoustic tomography and magnetic resonance imaging of resting-state functional connectivity in the mouse brain.

ABSTRACT: Resting-state functional connectivity (rsFC) has been essential to elucidate the intricacy of brain organization, further revealing clinical biomarkers of neurological disorders. Although functional magnetic resonance imaging (fMRI) remains a cornerstone in the field of rsFC recordings, its interpretation is often hindered by the convoluted physiological origin of the blood-oxygen-level-dependent (BOLD) contrast affected by multiple factors. Here, we capitalize on the unique concurrent multiparametric hemodynamic recordings of a hybrid magnetic resonance optoacoustic tomography platform to comprehensively characterize rsFC in female mice. The unique blood oxygenation readings and high spatio-temporal resolution at depths provided by functional optoacoustic (fOA) imaging offer an effective

SUBMITTER: Gezginer I 

PROVIDER: S-EPMC11685406 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature