Genome-scale metabolic modelling reveals interactions and key roles of symbiont clades in a sponge holobiont.

ABSTRACT: Sponges harbour complex microbiomes and as ancient metazoans and important ecosystem players are emerging as powerful models to understand the evolution and ecology of symbiotic interactions. Metagenomic studies have previously described the functional features of sponge symbionts, however, little is known about the metabolic interactions and processes that occur under different environmental conditions. To address this issue, we construct here constraint-based, genome-scale metabolic networks for the microbiome of the sponge Stylissa sp. Our models define the importance of sponge-derived nutrients for microbiome stability and discover how different organic inputs can result in net heterotrophy or autotrophy of the symbiont community. The analysis further reveals the key role that a newly

SUBMITTER: Zhang S 

PROVIDER: S-EPMC11685487 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature