Brain Network Alterations in Chronic Spinal Cord Injury: Multilayer Community Detection Approach.

ABSTRACT: Neurological recovery in individuals with spinal cord injury (SCI) is multifaceted, involving mechanisms such as remyelination and perilesional spinal neuroplasticity, with cortical reorganization being one contributing factor. Cortical reorganization, in particular, can be evaluated through network (graph) analysis of interregional functional connectivity. This study aimed to investigate cortical reorganization patterns in persons with chronic SCI using a multilayer community detection approach on resting-state functional MRI data. Thirty-eight participants with chronic cervical or thoracic SCI and 32 matched healthy controls were examined. Significant alterations in brain community structures were observed in the SCI cohort, particularly within the sensorimotor network (SMN). Importantly

SUBMITTER: Farahani FV 

PROVIDER: S-EPMC11685503 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature