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Structural diversity of streptokinase and activation of human plasminogen.

ABSTRACT: The beta domain of streptokinase is required for plasminogen activation and contains a region of sequence diversity associated with infection and disease in group A streptococci. We report that mutagenesis of this polymorphic region does not alter plasminogen activation, which suggests an alternative function for this molecular motif in streptococcal disease.

SUBMITTER: Lizano S 

PROVIDER: S-EPMC1168554 | biostudies-literature | 2005 Jul

REPOSITORIES: biostudies-literature

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Structural diversity of streptokinase and activation of human plasminogen.

Lizano Sergio S   Johnston Kenneth H KH  

Infection and immunity 20050701 7

The beta domain of streptokinase is required for plasminogen activation and contains a region of sequence diversity associated with infection and disease in group A streptococci. We report that mutagenesis of this polymorphic region does not alter plasminogen activation, which suggests an alternative function for this molecular motif in streptococcal disease. ...[more]

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