Prenatal gene-environment interactions mediate the impact of advanced maternal age on mouse offspring behavior.

ABSTRACT: Autism spectrum disorders encompass diverse neurodevelopmental conditions marked by alterations in social communication and repetitive behaviors. Advanced maternal age is associated with an increased risk of bearing children affected by autism but the etiological factors underlying this association are not well known. Here, we investigated the effects of advanced maternal age on offspring health and behavior in two genetically divergent mouse strains: the BTBR T⁺ Itpr3^tf/J (BTBR) mouse model of idiopathic autism, and the C57BL/6 J (B6) control strain, as a model of genetic variability. In both strains, advanced maternal age negatively affected female reproductive and pregnancy outcomes, and perturbed placental and fetal growth, and the expression of genes in the fetal

SUBMITTER: Zietek MM 

PROVIDER: S-EPMC11685589 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature