Learned phenotypes emerge during social stress modifying hippocampal orexin receptor gene expression.

ABSTRACT: Psychological distress, including anxiety or mood disorders, emanates from the onset of chronic/unpredictable stressful events. Symptoms in the form of maladaptive behaviors are learned and difficult to treat. While the origin of stress-induced disorders seems to be where learning and stress intersect, this relationship and molecular pathways involved remain largely unresolved. The hippocampus, studied for its role in learning, is divided into regions that designate the passage of neuronal signaling during memory formation, including dentate gyrus (DG), CA₃, CA₂, and CA₁. Inputs into these hippocampal subregions, like those from hypothalamic orexinergic neurons, may modify learning outcomes. We have previously shown the orexin system to balance stress state

SUBMITTER: Yaeger JDW 

PROVIDER: S-EPMC11685668 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature