MiR-196a2 rs11614913 C Allele is Associated with Increased Wilms Tumor Susceptibility in Chinese Children.

ABSTRACT: Wilms tumor, also known as nephroblastoma, is the most common kidney cancer in children. The miR-196a2 rs11614913 T>C polymorphism has been identified as a susceptibility locus in various adult cancers. However, it is unclear whether this polymorphism also increases the risk of pediatric cancer. In this study, we examined the genotypes of miR-196a2 rs11614913 T>C in 416 pediatric patients with Wilms tumor and 936 age- and gender-matched healthy controls of Chinese Han ethnicity using the TaqMan technology. The association between rs11614913 T>C polymorphism and the susceptibility to Wilms tumor was analyzed by univariable and multivariable logistic regression analyses, and the odds ratio (OR) and 95% confidence interval (CI) were calculated. Overall analysis indicated that th

SUBMITTER: Luo M 

PROVIDER: S-EPMC11685685 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature