Phospholipase PlcH is involved in the secretion of cell wall glycoproteins and contributes to the host immune response of Aspergillus fumigatus.

ABSTRACT: Glycosylphosphatidylinositol (GPI) anchoring is one of the conserved posttranslational modifications in eukaryotes that attach proteins to the plasma membrane. In fungi, in addition to plasma membrane GPI-anchored proteins (GPI-APs), some GPI-APs are specifically released from the cell membrane, secreted into the cell wall, and covalently linked to cell wall glucans as GPI-anchored cell wall proteins (GPI-CWPs). However, it remains unclear how fungal cells specifically release GPI-CWPs from their membranes. In this study, phospholipase PlcH was identified and confirmed as a phospholipase C that hydrolyzes phosphate ester bonds to release GPI-APs from the membrane of the opportunistic fungal pathogen Aspergillus fumigatus. Deletion of the plcH gene led to abnormal conidiation,

SUBMITTER: Hao J 

PROVIDER: S-EPMC11685838 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature