Neutral drift upon threshold-like selection promotes variation in antibiotic resistance phenotype.

ABSTRACT: Heritable phenotypic variation plays a central role in evolution by conferring rapid adaptive capacity to populations. Mechanisms that can explain genetic diversity by describing connections between genotype and organismal fitness have been described. However, the difficulty of acquiring comprehensive data on genotype-phenotype-environment relationships has hindered the efforts to explain how the ubiquitously observed phenotypic variation in populations emerges and is maintained. To address this challenge, we establish an experimental system where we can examine the genotype-phenotype relationships in a controlled environment. We perform long-term experimental evolution on VIM-2 β-lactamase, an antibiotic-resistance enzyme, to explore the conditions that promote the emergence and maintenan

SUBMITTER: Erdogan AN 

PROVIDER: S-EPMC11685847 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature