Femtomolar hydrogen sulfide detection via hybrid small-molecule nano-arrays.

ABSTRACT: Early disease diagnosis hinges on the sensitive detection of signaling molecules. Among these, hydrogen sulfide (H₂S) has emerged as a critical player in cardiovascular and nervous system signaling. On-chip immunoassays, particularly nanoarray-based interfacial detection, offer promising avenues for ultra-sensitive analysis due to their confined reaction volumes and precise signal localization. Beyond the DNA or protein biomolecules array, this work presents a promising hybrid small molecule nano-array for H₂S detection, using the power of dual molecules: a dye for fluorescence emission and a quencher with specific H₂S reactivity. Upon H₂S interaction, the quenched fluorescence reignites, creating an easily detectable array of bright spots. The m

SUBMITTER: Xing X 

PROVIDER: S-EPMC11685894 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature