A sterilization method for human decellularized vaginal matrices.

ABSTRACT: Vaginal reconstruction is necessary for various congenital and acquired conditions, including vaginal aplasia, trauma, tumors, and gender incongruency. Current surgical and non-surgical treatments often result in significant complications. Decellularized vaginal matrices (DVMs) from human tissue offer a promising alternative, but require effective sterilization to ensure safety and functionality. This study aimed to develop a sterilization method for decellularized human vaginal wall scaffolds. Based on our previously implemented decellularization technique with minor modifications, we designed and examined three sterilization methods consisting of (i) chemical decellularization, (ii) decellularization with additional peracetic acid/hydrogen peroxide (PAA/H₂O₂); (iii)

SUBMITTER: Sueters J 

PROVIDER: S-EPMC11685901 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature