Role of homeostatic plasticity in critical brain dynamics following focal stroke lesions.

ABSTRACT: Can focal brain lesions, such as those caused by stroke, disrupt critical brain dynamics? What biological mechanisms drive its recovery? In a recent study, we showed that focal lesions generate a sub-critical state that recovers over time in parallel with behavior (Rocha et al., Nat. Commun. 13, 2022). The loss of criticality in a cohort of stroke patients was associated with structural brain disconnections, while its recovery was accompanied by the re-modeling of specific white-matter tracts. These results were challenged by Janarek et al. (Sci. Rep. 13, 2023), who proposed an alternative interpretation for the anomalous monotonic decaying of the second cluster size, which is the neural signature originally used to infer loss of criticality. The present study tackles this controversy and

SUBMITTER: Rocha RP 

PROVIDER: S-EPMC11685905 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature