Exome-wide genetic risk score (ExGRS) to predict high myopia across multi-ancestry populations.

ABSTRACT:

Background

High myopia (HM), characterized by a severe myopic refractive error, stands as a leading cause of visual impairment and blindness globally. HM is a multifactorial ocular disease that presents high genetic heterogeneity. Employing a genetic risk score (GRS) is useful for capturing genetic susceptibility to HM.

Methods

This study assesses the effectiveness of these strategies via incorporating rare variations into the GRS assessment. This study enrolled two independent cohorts: 12,600 unrelated individuals of Han Chinese ancestry from Myopia Associated Genetics and Intervention Consortium (MAGIC) and 8682 individuals of European ancestry from UK Biobank (UKB).

Results

Here, we first estimate the heritability of HM resulting in 0.53 (standard error, 0.06) in t

SUBMITTER: Yuan J 

PROVIDER: S-EPMC11685959 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature