Association between constipation and incident chronic kidney disease in the UK Biobank study.

ABSTRACT: Despite previous studies supporting a close relationship between constipation and chronic kidney disease (CKD), the potential impact of constipation on incident CKD and the role of laxatives remains uncertain. We analyzed longitudinal data from the UK Biobank, which links baseline assessment data with follow-up data from hospital episode statistics and general practice records. Constipation was defined with diagnostic codes or regular use of laxatives at baseline as reported in the questionnaire. Cox proportional hazard models were used to evaluate the association between constipation and incident CKD. After excluding individuals with pre-existing CKD or missing covariates, 118,020 participants with general practice follow-up data were included in the main analysis. Over a median follow-up

SUBMITTER: Kim K 

PROVIDER: S-EPMC11686077 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature