Sodium dodecyl sulfate-coated silver nanoparticles accelerate antimicrobial potentials by targeting amphiphilic membranes.

ABSTRACT: Compelling concerns about antimicrobial resistance and the emergence of multidrug-resistant pathogens call for novel strategies to address these challenges. Nanoparticles show promising antimicrobial activities; however, their actions are hindered primarily by the bacterial hydrophilic-hydrophobic barrier. To overcome this, we developed a method of electrochemically anchoring sodium dodecyl sulfate (SDS) coatings onto silver nanoparticles (AgNPs), resulting in improved antimicrobial potency. We then investigated the antimicrobial mechanisms and developed therapeutic applications. We demonstrated SDS-coated AgNPs with anomalous dispersive properties capable of dispersing in both polar and nonpolar solvents and, further, detected significantly higher bacteriostatic and bactericidal effects c

SUBMITTER: Jin X 

PROVIDER: S-EPMC11686091 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature