Personalized modeling of gut microbiome metabolism throughout the first year of life.

ABSTRACT:

Background

Early-life exposures including diet, and the gut microbiome have been proposed to predispose infants towards multifactorial diseases later in life. Delivery via Cesarian section disrupts the establishment of the gut microbiome and has been associated with negative long-term outcomes. Here, we hypothesize that Cesarian section delivery alters not only the composition of the developing infant gut microbiome but also its metabolic capabilities. To test this, we developed a metabolic modeling workflow targeting the infant gut microbiome.

Methods

The AGORA2 resource of human microbial genome-scale reconstructions was expanded with a human milk oligosaccharide degradation module. Personalized metabolic modeling of the gut microbiome was performed for a cohort of 20 infa

SUBMITTER: Shaaban R 

PROVIDER: S-EPMC11686179 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature