Mapping quantitative trait loci regions associated with Marek's disease on chicken autosomes by means of selective DNA pooling.

ABSTRACT: Marek's Disease (MD), which can result in neurological damage and tumour formation, has large effects on the economy and animal welfare of the poultry industry worldwide. Previously, we mapped autosomal MD QTL regions (QTLRs) by individual genotyping of an F₆ population from a full-sib advanced intercross line. We further mapped MD QTLRs on the chicken Z chromosome (GGZ) using the same F₆ population, and by selective DNA pooling (SDP) of 8 elite egg production lines. Here we used SDP of the same pools used on GGZ to map autosomal MD QTLRs. Thirty-seven QTLRs were found. Seven of the QTLRs were tested by all sires from the same 8 lines, individually genotyped for QTLR markers. Five of the tested QTLRs were confirmed. Linkage disequilibrium (LD) was calculated for all Q

SUBMITTER: Lipkin E 

PROVIDER: S-EPMC11686186 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature