Wearable non-invasive neuroprosthesis for targeted sensory restoration in neuropathy.

ABSTRACT: Peripheral neuropathy (PN), the most common complication of diabetes, leads to sensory loss and associated health issues as pain and increased fall risk. However, present treatments do not counteract sensory loss, but only partially manage its consequences. Electrical neural stimulation holds promise to restore sensations, but its efficacy and benefits in PN damaged nerves are yet unknown. We designed a wearable sensory neuroprosthesis (NeuroStep) providing targeted neurostimulation of the undamaged nerve portion and assessed its functionality in 14 PN participants. Our system partially restored lost sensations in all participants through a purposely calibrated neurostimulation, despite PN nerves being less sensitive than healthy nerves (N = 22). Participants improved cadence and functiona

SUBMITTER: Gozzi N 

PROVIDER: S-EPMC11686223 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature