Characterization of breast cancer tumors in older patients who show de novo resistance to endocrine therapy.

ABSTRACT: The standard treatment for hormone receptor-positive breast cancer in good general condition is curative surgery followed by endocrine therapy. However, for older patients, endocrine therapy alone is sometimes chosen instead of curative surgery due to health conditions or personal preference, though this is not yet a standard approach. It is crucial to develop elderly-specific treatment strategies, potentially establishing endocrine therapy alone as a standard option. While endocrine therapy is generally effective, some patients show disease progression from the beginning due to de novo resistance. Hence, identifying such tumors is essential to determine who may benefit from endocrine therapy alone. Fifty-one patients aged over 70 years with estrogen receptor-positive and human epidermal g

SUBMITTER: Ishizuka Y 

PROVIDER: S-EPMC11686229 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature