Identification of novel therapeutic targets for head and neck squamous cell carcinoma through bioinformatics analysis.

ABSTRACT: Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous cancer with limited therapeutic options. Using publicly available datasets, we identified the WD repeat domain 54 (WDR54) gene as a potential therapeutic target in HNSCC. Gene expression profiling interactive analysis version 2 (GEPIA2) was used to identify genes differentially overexpressed in HNSCC. Our results showed that WDR54, a member of the WD40 repeat domain family, was overexpressed in HNSCC tumor samples. Analysis of three gene expression omnibus datasets showed that WDR54 was overexpressed in tumor samples. Using the UALCAN database, we showed that WDR54 expression in patients with HNSCC at different tumor stages gradually increased with disease progression. We confirmed the association between WDR54 and metastasis

SUBMITTER: Jeong EJ 

PROVIDER: S-EPMC11686289 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature