Exploring purine analogues as inhibitors against Katanin, a microtubule severing enzyme using molecular modeling approach.

ABSTRACT: Katanin, a key protein in cellular architecture, plays a crucial role in severing microtubules, which are vital components of the cytoskeleton. Given its central involvement in cell division and proliferation, katanin represents a promising target for therapeutic intervention, particularly in cancer treatment. Inhibiting katanin's function could potentially hinder the uncontrolled growth of cancerous cells, making it an attractive target for novel anti-cancer therapies. Previous studies have shown that purine-based compounds exhibit a strong affinity for microtubule-severing enzymes. In this study, we aim to identify potential purine-type inhibitors of katanin using molecular modeling techniques. A total of 276,280 purine-type compounds from the PubChem database were subjected to structure

SUBMITTER: Saxena V 

PROVIDER: S-EPMC11686324 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature