Cancer-specific innate and adaptive immune rewiring drives resistance to PD-1 blockade in classic Hodgkin lymphoma.

ABSTRACT: Hodgkin Reed-Sternberg (HRS) cells of classic Hodgkin lymphoma (cHL), like many solid tumors, elicit ineffective immune responses. However, patients with cHL are highly responsive to PD-1 blockade, which largely depends on HRS cell-specific retention of MHC class II and implicates CD4⁺ T cells and additional MHC class I-independent immune effectors. Here, we utilize single-cell RNA sequencing and spatial analysis to define shared circulating and microenvironmental features of the immune response to PD-1 blockade in cHL. Compared with non-responders, responding patients have more circulating CD4⁺ naïve and central memory T cells and B cells, as well as more diverse CD4⁺ T cell and B cell receptor repertoires. Importantly, a population of circulating and tumo

SUBMITTER: Paczkowska J 

PROVIDER: S-EPMC11686379 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature