Longevity of antibody responses is associated with distinct antigen-specific B cell subsets early after infection.

ABSTRACT:

Introduction

Upon infection, T cell-driven B cell responses in GC reactions induce memory B cells and antibody-secreting cells that secrete protective antibodies. How formation of specifically long-lived plasma cells is regulated via the interplay between specific B and CD4+ T cells is not well understood. Generally, antibody levels decline over time after clearance of the primary infection.

Method

In this study, convalescent individuals with stable RBD antibody levels (n=14, "sustainers") were compared with donors (n=13) with the greatest antibody decline from a cohort of 132. To investigate the role of the cellular immune compartment in the maintenance of antibody levels, SARS-CoV-2-specific responses at 4 to 6 weeks post-mild COVID-19 infection were characterized using de

SUBMITTER: Kuijper LH 

PROVIDER: S-EPMC11686410 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature