Alcohol Use Disorder Polygenic Score Compared With Family History and ADH1B.

ABSTRACT:

Importance

Identification of individuals at high risk of alcohol use disorder (AUD) and subsequent application of prevention and intervention programs has been reported to decrease the incidence of AUD. The polygenic score (PGS), which measures an individual's genetic liability to a disease, can potentially be used to evaluate AUD risk.

Objective

To assess the estimability and generalizability of the PGS, compared with family history and ADH1B, in evaluating the risk of AUD among populations of European ancestry.

Design, setting, and participants

This genetic association study was conducted between October 1, 2023, and May 21, 2024. A 2-stage design was used. First, the pruning and thresholding method was used to calculate PGSs in the screening stage. Second, the esti

SUBMITTER: Lai D 

PROVIDER: S-EPMC11686414 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature