Histopathologic Analysis of Human Kidney Spatial Transcriptomics Data: Toward Precision Pathology.

ABSTRACT: The application of spatial transcriptomics (ST) technologies is booming and has already yielded important insights across many different tissues and disease models. In nephrology, ST technologies have helped to decipher the cellular and molecular mechanisms in kidney diseases and have allowed the recent creation of spatially anchored human kidney atlases of healthy and diseased kidney tissues. During ST data analysis, the computationally annotated clusters are often superimposed on a histologic image without their initial identification being based on the morphologic and/or spatial analyses of the tissues and lesions. Herein, histopathologic ST data from a human kidney sample were modeled to correspond as closely as possible to the kidney biopsy sample in a health care or research context.

SUBMITTER: Isnard P 

PROVIDER: S-EPMC11686452 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature