Unraveling the Causal Relationship Between Blood Metabolites and Acne: A Metabolomic Mendelian Randomization Study.

ABSTRACT:

Background

Acne is a common skin disorder that may be linked to metabolic dysfunction. However, the causal impact of blood metabolites on acne has not been thoroughly investigated.

Methods

We performed a metabolome-wide Mendelian randomization (MR) analysis on 486 blood metabolites and acne using a genome-wide association dataset. The study included preliminary inverse-variance weighted (IVW) analysis, multivariable MR analysis, linkage disequilibrium score (LDSC) analysis, and colocalization analysis, along with reverse MR to address potential reverse causation.

Results

Our analysis identified 12 metabolites significantly associated with acne. LDSC analysis revealed a genetic correlation between nonanoylcarnitine and acne. Colocalization analysis confirmed shared gen

SUBMITTER: Li M 

PROVIDER: S-EPMC11686570 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature